Meg and Chris
In “Nanny Goats” the Griffins hire a Russian nanny, who has a hit out on her. When assassins storm the house she flees with Stewie and walks in on Chris and Meg playing doctor.
In “Fifteen Minutes of Shame” Chris spies on Meg’s slumber party. Lois joins in and suggests they practice kissing. Chris is discovered masturbating and Lois tells him to finish up (6:00). The Griffins do a reality TV show and replace Meg with a sexy blonde girl, who Chris hits on by explaining that they normally eat breakfast naked and he films it (17:30)
In “Halloween on Spooner Street” Meg and Chris kiss in the closet game.
In “Save the Clam” Chris stands in for a corpse and Meg has to scratch his balls for him (19:40).
In “Fresh Heir” Meg tells Chris their bath is ready but Peter hears her and awkwardness ensues.
In “High School English” Peter reads Of Mice and Men starring Meg as Curley’s wife and Chris as Lenny, a large mentally handicapped man. Curley’s wife tries to seduce Lenny. “I want you to destroy me,” she tells him. He takes her literally and snaps her neck.
Stewie and Brian
In “Stewie is Enceinte” Stewie impregnates himself with Brian’s child in order to bring them closer together.
In “Go, Stewie, Go!” Stewie pretends to be a girl for a part on his favorite television show. He tests out his alter ego “Karina Smirnoff” on Brian, who tries to get a handjob.
In “We Love You, Conrad” Stewie pretends to be Brian’s girlfriend, Desiree.
In “Saving Private Brian” Stewie and Brian pretend to gay in order to get kicked out of the army.
In “420” Stewie gets naked to supply Brian with urine for a drug test.
In “Movin’ Out (Brian’s Song)” Stewie suggests Brian get back at his girlfriend Jillian by having sex with the first person he sees (i.e.; Stewie).
In “Hell Comes to Quahog” Stewie asks Brian to spit on him and call him scum. Brian asks “How will that cool you off?” But clearly that wasn’t the point.
In “Quagmire’s Baby” Stewie makes Brian stroke his tail in exchange for a clone.
In “The Tan Aquatic with Steve Zissou” Mr. Furley from Three’s Company walks in on Brian squirting lotion on Stewie, which looks like facial.
In “PTV” Peter sings the FCC censorship song, which includes a scene of Peter, Brian and Stewie having a pillowfight and another scene in which Stewie and Brian engage in S&M.
In “The Woof of Wall Street” Stewie teaches Brian how to invest in the stock market. They become so successful they have to make a sappy investment commercial. Brian is the father of the bride portrayed by Stewie, who insists on marrying him.
“Fidelity, we’re there for you when your baby marries his dog dad,” the commercial announcer declares. (7:03)